閉経後女性における10年間の心血管疾患リスクと骨折発生率の関連性：女性の健康イニシアチブからの前向き解析
The association between 10-year cardiovascular risk and fracture incidence in postmenopausal women: a prospective analysis from the Women's Health Initiative.
Hossain Rafeka, Laddu Deepika, Crandall Carolyn J, Ensrud Kristine E ほか — Lancet regional health. Americas
AI要約
閉経後女性では、10年間の心血管疾患（CVD）リスクが高いほど、主要な骨粗鬆症性骨折や股関節骨折のリスクも高まることが、21,000人以上のデータから判明しました。CVDリスクの評価は、骨折リスクの高い女性を特定するのに役立つ可能性があります。
AI生成の要約です — 原文を読む
Abstract（原文）
BACKGROUND: Cardiovascular disease (CVD) and fractures share pathophysiological mechanisms, yet the relationship between predicted CVD risk and fracture incidence remains unexplored. Using the PREventing cardiovascular disease eVENTs (PREVENT) score, this study aimed to determine the association between CVD risk and incident fractures in postmenopausal women. METHODS: This study included 21,300 participants from the Women's Health Initiative (WHI) (1993-2024). PREVENT 10-year CVD risk was categorized as low (<5·0%), borderline (5·0%-7·4%), intermediate (7·5%-19·9%), or high (≥20·0%). Cox proportional hazards models estimated adjusted hazard ratios [HR (95% CI)] for incident fractures, including any clinical, major osteoporotic fracture (MOF), and hip fracture. FINDINGS: In the sample [mean (SD) age: 63·7 (7·3) years], 9224 (43·3%) experienced any clinical fracture, 4997 (23·5%) MOF, and 1717 (8·1%) hip fractures. Overall, 5370 (25·2%) had low, 4169 (19·6%) borderline, 10,661 (50·1%) intermediate, and 1100 (5·2%) high CVD risk. In fully adjusted models, compared with low-CVD risk, higher risk of MOF was observed in the intermediate- [1·14 (1·04-1·24)] and high- [1·22 (1·07-1·40)] CVD risk groups; and higher risk of hip fracture [intermediate: 1·33 (1·14-1·56); high: 1·93 (1·55-2·42)]. Associations attenuated after accounting for the competing risk of mortality, but higher CVD risk remained associated with higher fracture risk. INTERPRETATION: A higher 10-year predicted CVD risk was associated with higher MOF and hip fracture risk after adjustment for sociodemographic, lifestyle, and clinical factors. CVD risk may have implications for fracture risk assessment in postmenopausal women. FUNDING: WHI is funded by the US National Heart, Lung, and Blood Institute. No additional funding was received for this study.
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出典: PubMed (PMID: 42163933)。AI要約は情報提供のみを目的とし、医療的アドバイスを構成するものではありません。