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タンパク質2026-05

若年健常成人における、組換えウシβ-ラクトグロブリン、乳由来ホエイ、または炭水化物補給後の損傷性運動による筋肉回復と筋原線維タンパク質合成

Muscle Recovery and Myofibrillar Protein Synthesis after Damaging Exercise with Recombinant Bovine β-Lactoglobulin, Dairy-Derived Whey or Carbohydrate Supplementation in Young Healthy Adults.

Rogers Lucy M, Korzepa Marie, Belfield Archie E, Quinlan Jonathan I ほかThe Journal of nutrition

AI要約

この研究は、健康な若年成人が激しい運動後に、組換えウシβ-ラクトグロブリン(rBLG)やホエイプロテインといった追加のタンパク質サプリメントが筋肉の回復と修復を改善するかどうかを調べました。参加者はすでに毎日適度な量のタンパク質(体重1kgあたり約0.9g)を摂取していました。結果として、追加のrBLGやホエイプロテインを摂取しても、炭水化物プラセボと比較して、筋肉の回復やタンパク質合成の速度が有意に向上することはありませんでした。これは、十分なタンパク質を摂取している人にとって、損傷性運動からの回復を早めるために追加のタンパク質サプリメントは効果が限定的である可能性を示唆しています。

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Abstract(原文)

BACKGROUND: Supplementation with recombinant bovine β-lactoglobulin (rBLG), a precision-engineered mimetic of dairy-derived whey, supports similar resistance exercise (RE) training-induced muscle remodeling to whey protein (WHEY). However, the influence of rBLG on recovery indices and muscle protein synthesis rates after damaging exercise is unknown. OBJECTIVES: To determine the influence of rBLG supplementation on indices of muscle recovery and integrated myofibrillar protein synthesis (iMyoPS) over 72 h following damaging RE, compared with WHEY and a carbohydrate placebo. METHODS: In a randomized double-blind, placebo-controlled, parallel-group design, 27 healthy adults consuming a controlled diet (∼0.9 g/kg body mass/d of protein) were supplemented thrice daily with 0.3 g/kg body mass of rBLG, WHEY, or isocaloric carbohydrate placebo for 3 d following an acute bout of damaging lower-body RE (8 × 10 maximal, unilateral, eccentric knee extensions). Consumption of deuterated water combined with serial vastus lateralis muscle biopsies permitted the measurement of iMyoPS 72 h before (habitual) and after RE. Knee extensor maximum voluntary contraction (MVC), muscle soreness, and plasma concentrations of creatine kinase and lactate dehydrogenase (LDH) were also assessed post-RE to characterize muscle recovery. RESULTS: iMyoPS fractional synthetic rate (%/d) increased following damaging RE (P < 0.001), with no significant differences between groups. Knee extensor MVC decreased, and subjective muscle soreness and plasma LDH concentrations increased following strenuous exercise (P < 0.05 for all) with no significant differences between groups. CONCLUSIONS: At habitual dietary protein intakes ∼0.9 g/kg body mass/d, further rBLG or WHEY supplementation did not influence muscle recovery or iMyoPS rates, suggesting that protein supplementation, at the intakes studied, may have limited efficacy as a tool to enhance muscle recovery and remodeling from damaging exercise.

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出典: PubMed (PMID: 41500363)。AI要約は情報提供のみを目的とし、医療的アドバイスを構成するものではありません。