ビタミンD欠乏症の治療は、非代償性肝硬変患者における炎症性貧血の改善と関連する
Treatment of Hypovitaminosis D Is Associated with Improvement in Anemia of Inflammation in Patients with Decompensated Cirrhosis.
Diaz-Ruiz Raquel, Poca Maria, Roman Eva, Cuyàs Berta ほか — Medical sciences (Basel, Switzerland)
AI要約
非代償性肝硬変の患者は、ビタミンD欠乏症と炎症性貧血を併発することがよくあります。この研究では、ビタミンDと他の栄養素を3ヶ月間補給することで、これらの患者のヘモグロビン値が有意に改善し、炎症マーカーも減少することが示されました。この結果は、ビタミンD欠乏症の治療が、全身の炎症を抑えることで、非代償性肝硬変患者の貧血管理に役立つ可能性を示唆しています。
AI生成の要約です — 原文を読む
Abstract（原文）
: Anemia of inflammation (AI) is a prevalent condition linked to systemic inflammation in several chronic diseases, including chronic liver diseases. Hypovitaminosis D is frequently identified in patients with chronic diseases, and its pathogenic role in anemia is currently under investigation. The aim of this study was to prospectively investigate changes in hemoglobin concentration and inflammatory markers in vitamin D-deficient/-insufficient patients with decompensated cirrhosis after initiating vitamin D supplementation, in addition to the supplementation of other micronutrients if needed. : Patients with cirrhosis discharged from decompensation were assessed at baseline and 3 months after vitamin D supplementation. Laboratory parameters of red cell series, nutrition, and micronutrients were assessed in both visits, together with markers of systemic inflammation. : Thirty-nine patients were included in the study, of whom 33 completed the 3-month evaluation and were analyzed [age: 62.7 ± 10.7 years; gender: n = 29 (87.9%) males; Charlson index: 5.9 ± 1.6; Model for End-Stage Liver Disease (MELD): 12.4 ± 4.5; baseline hemoglobin (Hb): 11.7 ± 1.8 g/dL (anemia n = 24 (72.7%)); mean 25-hydroxyvitamin D (25OHD) plasma level: 15.5 ± 8.6 µg/L]. A significant increase in plasma 25OHD (40.1 ± 17.8, < 0.001) and in Hb (12.4 ± 2.0, = 0.01) was observed at 3 months with a decrease in the prevalence of anemia (n = 17, = 0.015) and of Interleukin 6 in plasma levels [IL-6, 10.7 (5.8-23.3) vs. 6.5 (4.1-11.8), = 0.016]. A greater rise in hemoglobin was correlated with higher plasma IL-6 concentration at baseline. Milder anemia and indexes of hypoferremia at baseline, along with optimal renal function and plasma levels of 25OHD at 3 months, were linked to resolution of anemia. : Treating vitamin D deficiency together with other micronutrient deficits is associated with inflammation amelioration and improvement in anemia in patients with cirrhosis following discharge from acute decompensation. This paper supports the potential role of vitamin D in the management of anemia in patients with decompensated cirrhosis by modulating systemic inflammation.
このコラムに関連する書籍
ビタミンD不足が招く病気――骨・免疫・うつに効く正しい補充法
骨代謝・予防医学関連書籍
ビタミンD欠乏の実態と健康への影響を最新研究で解説。食事・日光浴・サプリの正しい使い分けも紹介。
Amazonで本を見るビタミンDが摂れる魚・きのこレシピ
管理栄養士監修
鮭・さんま・しいたけなどビタミンDが豊富な食材を使ったレシピを季節ごとに紹介。
Amazonで本を見るAmazonのアソシエイトとして、栄養DBは適格販売により収入を得ています。
出典: PubMed (PMID: 42201059)。AI要約は情報提供のみを目的とし、医療的アドバイスを構成するものではありません。