閉経後骨粗しょう症の潜在的マーカーとしての炎症性および心血管関連指標の評価―後ろ向き研究
Evaluation of inflammatory and cardiovascular-related indices as potential markers for postmenopausal osteoporosis-a retrospective study.
Tigli Alihan, Baykus Yakup, Sener Nazli, De Girmenci Yasemin Ercan ほか — PeerJ
AI要約
この研究は、閉経後骨粗しょう症の診断に、特定の炎症性および心血管関連の血液マーカーが役立つかを調べました。387人の閉経後女性のデータを分析し、骨粗しょう症の有無で単球/HDL-C比やトリグリセリド・グルコース指数などの様々な比率を比較しました。単球/HDL-C比は統計的な差を示しましたが、骨粗しょう症を確実に特定できるほど正確ではありませんでした。したがって、これらのマーカーは閉経後骨粗しょう症の単独のスクリーニングツールとしては推奨されません。
AI生成の要約です — 原文を読む
Abstract（原文）
BACKGROUND: Emerging evidence suggests a strong pathophysiological link between osteoporosis (OP), characterized by low bone mineral density (BMD), and cardiovascular disease. Biomarkers such as the atherogenic index of plasma (AIP) and the triglyceride-glucose (TyG) index, while primarily linked to cardiovascular risk, may also reflect the metabolic dysregulation seen in OP. Similarly, inflammatory markers including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), and neutrophil-monocyte ratio (NMR), along with ratios like lymphocyte/HDL-C, monocyte/HDL-C, and granulocyte/HDL-C have been suggested as potential diagnostic tools. The aim of this study was to evaluate the diagnostic discrimination of these accessible biomarkers for postmenopausal OP. METHODS: A retrospective analysis was performed on 387 postmenopausal women who underwent bone densitometry between 2021 and 2025. Data on body mass index (BMI), T-scores, age, menopause duration, and relevant laboratory parameters were collected. Inflammatory and biochemical indices were calculated using established formulas. RESULTS: Age and menopause duration were significantly higher in the OP group compared to the normal and osteopenia groups ( < 0.01). Conversely, the median femoral neck T-score (FN-T) was significantly lower in the OP group. Among the biomarkers, only the monocyte/HDL-C ratio was significantly lower in the OP group ( < 0.05). Receiver operating characteristic (ROC) analysis indicated poor diagnostic discrimination for the monocyte/HDL-C ratio (AUC: 0.608), while all other biomarkers were non-significant (AUC < 0.6). CONCLUSION: Even the statistically significant monocyte/HDL-C ratio failed to achieve clinically acceptable discriminatory ability. Consequently, these biomarkers cannot be recommended as standalone screening tools for postmenopausal osteoporosis.
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出典: PubMed (PMID: 42369761)。AI要約は情報提供のみを目的とし、医療的アドバイスを構成するものではありません。