腸骨軸：骨の健康のための微生物代謝と栄養介入
The gut-bone axis: microbial metabolism and nutritional interventions for bone health.
Rodriguez-Bryant Alba, Papageorgiou Maria, Horcajada Marie-Noëlle, Biver Emmanuel ほか — Gut microbes
AI要約
この論文は「腸骨軸」について掘り下げ、腸内細菌とその代謝物が骨の健康維持に重要な役割を果たすことを強調しています。これらの微生物は、栄養吸収、pHバランス、免疫反応を通じて骨の強度に影響を与えます。特定の食事パターンやプロバイオティクス、プレバイオティクスなどの栄養戦略が、加齢に伴う骨量減少を防ぐ有望な方法であることを示唆しています。
AI生成の要約です — 原文を読む
Abstract（原文）
Osteoporosis is a prevalent condition characterized by a rapid decline in bone mineral density and distorted microarchitecture, which leads to increased bone fragility. The gut microbiota and its metabolites play a crucial role in the development and progression of osteoporosis by influencing gut permeability, nutrient digestion and absorption, pH balance, and immune regulation. Nutritional interventions aimed at modulating gut microbiota, through postbiotics (butyrate), probiotics ( or ), prebiotics (fructo-oligosaccharides), synbiotics, and specific dietary patterns (e.g. Mediterranean and vegetarian diets) have emerged as promising strategies to mitigate bone loss associated with aging. This review investigates the communication between the gut and bone, summarizing the underlying mechanisms and providing an updated review on microbial metabolites. Additionally, it examines recent research on probiotics and their metabolic contributions, highlighting potential gaps in the current understanding of this field.
出典: PubMed (PMID: 42171633)。AI要約は情報提供のみを目的とし、医療的アドバイスを構成するものではありません。